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F-Box-WD Repeat-Containing Protein 7 MeSH Descriptor Data 2022


MeSH Heading
F-Box-WD Repeat-Containing Protein 7
Tree Number(s)
D08.811.464.938.750.750.750
D12.776.157.169.750
D12.776.167.242
Unique ID
D000073979
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000073979
Scope Note
A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
Entry Term(s)
F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein
Registry Number
0
Previous Indexing
Cell Cycle Proteins (2006-2017)
F-Box Proteins (2006-2017)
Ubiquitin-Protein Ligases (2006-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/02/27
F-Box-WD Repeat-Containing Protein 7 Preferred
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