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Valosin Containing Protein MeSH Descriptor Data 2022


MeSH Heading
Valosin Containing Protein
Tree Number(s)
D08.811.277.040.013.500.750
D08.811.277.040.025.024.750
D12.776.157.025.750.750
D12.776.167.800
Unique ID
D000074405
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074405
Scope Note
A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.
Entry Term(s)
CDC48 Protein
Cell Cycle Protein CDC48
Cell Cycle Protein CDC48p
Valosin-Containing Protein
Valosine-Containing Protein
p97 Valosin-Containing Protein
Registry Number
EC 3.6.4.6
Public MeSH Note
2018; VALOSIN CONTAINING PROTEIN was indexed under ADENOSINE TRIPHOSPHATASES and CELL CYCLE PROTEINS 1991-2017
History Note
2018 (1991)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/06/02
Valosin Containing Protein Preferred
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