MeSH Browser

MeSH Heading: Amyotrophic Lateral Sclerosis
Tree Number(s): C10.228.854.139; C10.574.562.250; C10.574.950.050; C10.668.467.250; C18.452.845.800.050
Unique ID: D000690
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000690
Scope Note: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Entry Version: ALS
Entry Term(s): ALS - Amyotrophic Lateral Sclerosis; Amyotrophic Lateral Sclerosis With Dementia; Amyotrophic Lateral Sclerosis, Guam Form; Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam; Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1; Charcot Disease; Dementia With Amyotrophic Lateral Sclerosis; Gehrig's Disease; Guam Disease; Guam Form of Amyotrophic Lateral Sclerosis; Lou Gehrig Disease; Lou Gehrig's Disease; Lou-Gehrigs Disease; Motor Neuron Disease, Amyotrophic Lateral Sclerosis
NLM Classification #: WE 552
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/04/29

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

congenital (CN)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Spinal Cord Diseases [C10.228.854]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - Motor Neuron Disease [C10.574.562]

Nervous System Diseases [C10]
- Neurodegenerative Diseases [C10.574]
  - TDP-43 Proteinopathies [C10.574.950]
    - Amyotrophic Lateral Sclerosis [C10.574.950.050]
    - Frontotemporal Lobar Degeneration [C10.574.950.300]

Nervous System Diseases [C10]
- Neuromuscular Diseases [C10.668]
  - Motor Neuron Disease [C10.668.467]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Proteostasis Deficiencies [C18.452.845]
    - TDP-43 Proteinopathies [C18.452.845.800]
      - Amyotrophic Lateral Sclerosis [C18.452.845.800.050]
      - Frontotemporal Lobar Degeneration [C18.452.845.800.300]

Amyotrophic Lateral Sclerosis Preferred

Concept UI: M0001056
Scope Note: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Terms: Amyotrophic Lateral Sclerosis Preferred Term
Term UI T002090
Date01/01/1999
LexicalTag NON
ThesaurusID; Gehrig's Disease
Term UI T002091
Date04/14/1989
LexicalTag EPO
ThesaurusID NLM (1990); Charcot Disease
Term UI T840894
Date04/18/2013
LexicalTag EPO
ThesaurusID; Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Term UI T366064
Date11/08/1999
LexicalTag NON
ThesaurusID; Lou Gehrig's Disease
Term UI T002092
Date04/14/1989
LexicalTag EPO
ThesaurusID NLM (1990); Lou-Gehrigs Disease
Term UI T753625
Date06/30/2009
LexicalTag EPO
ThesaurusID; ALS - Amyotrophic Lateral Sclerosis
Term UI T000953133
Date03/18/2019
LexicalTag ABX
ThesaurusID NLM (2020); Lou Gehrig Disease
Term UI T366063
Date11/08/1999
LexicalTag EPO
ThesaurusID

Amyotrophic Lateral Sclerosis, Guam Form Narrower

Amyotrophic Lateral Sclerosis With Dementia Related

Amyotrophic Lateral Sclerosis MeSH Descriptor Data 2024