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Motor Neuron Disease MeSH Descriptor Data 2024

MeSH Heading
Motor Neuron Disease
Tree Number(s)
Unique ID
RDF Unique Identifier
general or unspecified; prefer specifics
Scope Note
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Entry Version
Entry Term(s)
Anterior Horn Cell Disease
Familial Motor Neuron Disease
Lateral Sclerosis
Lower Motor Neuron Disease
Motor Neuron Disease, Familial
Motor Neuron Disease, Lower
Motor Neuron Disease, Secondary
Motor Neuron Disease, Upper
Motor System Disease
Primary Lateral Sclerosis
Secondary Motor Neuron Disease
Upper Motor Neuron Disease
NLM Classification #
WE 550
Previous Indexing
Motor Neurons (1966-1991)
Neuromuscular Diseases (1972-1991)
Public MeSH Note
History Note
Date Established
Date of Entry
Revision Date
Motor Neuron Disease Preferred
Anterior Horn Cell Disease Narrower
Lateral Sclerosis Narrower
Motor Neuron Disease, Lower Narrower
Motor Neuron Disease, Upper Narrower
Motor Neuron Disease, Secondary Narrower
Familial Motor Neuron Disease Narrower
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