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Synucleinopathies MeSH Descriptor Data 2022


MeSH Heading
Synucleinopathies
Tree Number(s)
C10.574.928
C18.452.845.650
Unique ID
D000080874
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000080874
Scope Note
Neurodegenerative disorders involving deposition of abnormal ALPHA-SYNUCLEIN in dopaminergic neurons and glial cells in the brain. Pathological aggregations of alpha-synuclein proteins results in LEWY BODIES and Lewy neurites; melanin granules in the SUBSTANTIA NIGRA and LOCUS COERULEUS; and glial cytoplasmic inclusions. Synucleinopathies are associated with mutation in the ALPHA-SYNUCLEIN (SNCA) gene on chromosome 4. PARKINSON DISEASE; LEWY BODY DISEASE with dementia; and MULTIPLE SYSTEM ATROPHY are prominent examples of synucleinopathy.
Entry Term(s)
a-Synucleinopathies
alpha Synuclein Pathology
alpha-Synucleinopathies
Previous Indexing
Neurodegenerative Diseases (1998-2019)
alpha-Synuclein (1999-2019)
See Also
alpha-Synuclein
Lewy Bodies
Public MeSH Note
2020
History Note
2020
Date Established
2020/01/01
Date of Entry
2019/07/08
Revision Date
2019/05/17
Synucleinopathies Preferred
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