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Frontotemporal Lobar Degeneration MeSH Descriptor Data 2025
Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
Entry Term(s)
FTLD
Previous Indexing
Dementia (2002-2009)
Public MeSH Note
2010; see DEMENTIA 2000-2009; for SEMANTIC DEMENTIA see DEMENTIA 2000-2009
History Note
2010; use DEMENTIA 2000-2009; for SEMANTIC DEMENTIA use DEMENTIA 2000-2009
Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.