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Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.
Entry Term(s)
PTTG Protein
Pituitary Tumor-Transforming Gene Protein
Pituitary Tumor-Transforming Proteins
Registry Numbers
0
Previous Indexing
Neoplasm Proteins (1997-2013)
Public MeSH Note
2014; was indexed under NEOPLASM PROTEINS 1997-2013
Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.