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Spastin MeSH Descriptor Data 2022


MeSH Heading
Spastin
Tree Number(s)
D08.811.277.040.013.500.500
D08.811.277.040.025.024.500
D12.776.157.025.750.500
D12.776.220.600.450.465
D12.776.631.560.480
Unique ID
D000074181
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074181
Scope Note
An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.
Entry Term(s)
Spastic Paraplegia 4 Protein
Registry Number
EC 3.6.4.3
Previous Indexing
Adenosine Triphosphatases (1999-2017)
See Also
AAA Domain
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/03/01
Spastin Preferred
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