MeSH Browser

MeSH Heading: Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome
Tree Number(s): D08.811.464.938.750.092.996; D12.776.167.024.996
Unique ID: D064196
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064196
Scope Note: A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
Entry Term(s): Anapc8; Apc8 Subunit, Anaphase-Promoting Complex
Previous Indexing: Cell Cycle Proteins (1996-2013); Ligases (1996-2003); Ubiquitin-Protein Ligase Complexes (2004-2013)
Public MeSH Note: 2014; was indexed under UBIQUITIN-PROTEIN LIGASE COMPLEXES 2004-2013
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0580183
Scope Note: A highly conserved subunit of the anaphase-promoting complex (APC-C) containing multiple 34-amino-acid tetratricopeptide repeats. These domains, also found in Apc3, Apc6, and Apc7, have been shown to mediate protein-protein interactions, suggesting that Apc8 may assist in coordinating the juxtaposition of the catalytic and substrate recognition module subunits relative to coactivators and APC-C inhibitors.
Terms: Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome Preferred Term
Term UI T836616
Date01/31/2013
LexicalTag NON
ThesaurusID NLM (2014); Anapc8
Term UI T835356
Date01/09/2013
LexicalTag ABB
ThesaurusID NLM (2014); Apc8 Subunit, Anaphase-Promoting Complex
Term UI T835357
Date01/09/2013
LexicalTag ACX
ThesaurusID NLM (2014)

Apc8 Subunit, Anaphase-Promoting Complex-Cyclosome MeSH Descriptor Data 2024