- Concept UI
- Registry Number
- Scope Note
- A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
Apoptotic Protease-Activating Factor 1
Apaf-1 Protease-Activating Factor
Apoptotic Peptidase Activating Factor 1