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Apoptotic Protease-Activating Factor 1 MeSH Descriptor Data 2022


MeSH Heading
Apoptotic Protease-Activating Factor 1
Tree Number(s)
D12.644.360.024.131.124
D12.644.360.075.358.124
D12.776.157.057.006.124
D12.776.476.024.139.124
D12.776.476.075.358.124
Unique ID
D053477
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053477
Scope Note
A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.
Entry Term(s)
Apaf-1 Protease-Activating Factor
Apoptotic Peptidase Activating Factor 1
Registry Number
0
Public MeSH Note
2007; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 was indexed under INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS 1997-2006 & under PROTEINS 1997-2005
History Note
2007(1997)
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2016/04/15
Apoptotic Protease-Activating Factor 1 Preferred
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