- Concept UI
- M0493498
- Scope Note
- Multimeric protein complexes formed in the CYTOSOL that play a role in the activation of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.
- Terms
-
Apoptosomes
Preferred Term
Term UI
T663496
Date12/30/2005
LexicalTag
NON
ThesaurusID
NLM (2007)
-
Apoptosomal Protein Complex
Term UI
T663498
Date12/30/2005
LexicalTag
NON
ThesaurusID
NLM (2007)
-
Apoptosome
Term UI
T663497
Date12/30/2005
LexicalTag
NON
ThesaurusID
NLM (2007)