MeSH Browser

MeSH Heading: COP9 Signalosome Complex
Tree Number(s): D05.500.139; D08.811.037.750.250; D08.811.277.656.300.887.375
Unique ID: D000075686
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075686
Scope Note: A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Entry Term(s): COP9 Signalosome (CSN); COP9 Signalosome Subunit 1; COP9 Signalosome Subunit 2; COP9 Signalosome Subunit 3; COP9 Signalosome Subunit 4; COP9 Signalosome Subunit 5; COP9 Signalosome Subunit 6; COP9 Signalosome Subunit 7A; COP9 Signalosome Subunit 7B; COP9 Signalosome Subunit 8; COP9 Signalsome; Constitutive Photomorphogenesis 9 Signalosome; Constitutive Photomorphogenesis 9 Signalsome; FUSCA Protein 11; G Protein Pathway Suppressor 1; Sgn3; Signalosome Subunit 3
Registry Numbers: EC 3.4.19.12; 0
Public MeSH Note: 2018; COP9 SIGNALOSOME COMPLEX was indexed under PEPTIDE HYDROLASES and MULTIPROTEIN COMPLEXES 2006-207; under PROTEINS 1995-2005; and under PLANT PROTEINS 1995-1999; for COP9 SIGNALOSOME SUBUNIT 3 see SIGNALOSOME SUBUNIT 3 1998-2017; SIGNALOSOME SUBUNIT 3 was indexed under NUCLEAR PROTEINS and PROTEIN KINASES 1998-2017
History Note: 2018 (1995); for COP9 SIGNALOSOME SUBUNIT 3 use SIGNALOSOME SUBUNIT 3 1998-2017
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Multiprotein Complexes [D05.500]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Deubiquitinating Enzymes [D08.811.037]
    - Ubiquitin-Specific Proteases [D08.811.037.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Ubiquitin-Specific Proteases [D08.811.277.656.300.887]
        
        COP9 Signalosome Complex [D08.811.277.656.300.887.375]
        
        Tumor Necrosis Factor alpha-Induced Protein 3 [D08.811.277.656.300.887.750]
        
        Ubiquitin-Specific Peptidase 7 [D08.811.277.656.300.887.875]

COP9 Signalosome Complex Preferred

Concept UI: M0234074
Registry Numbers: EC 3.4.19.12
Scope Note: A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Terms: COP9 Signalosome Complex Preferred Term
Term UI T000923450
Date05/05/2017
LexicalTag ABX
ThesaurusID NLM (2005); COP9 Signalosome (CSN)
Term UI T644148
Date06/24/2005
LexicalTag ACX
ThesaurusID NLM (2005); COP9 Signalsome
Term UI T000926422
Date06/08/2017
LexicalTag ABX
ThesaurusID NLM (2018); Constitutive Photomorphogenesis 9 Signalsome
Term UI T000926423
Date06/08/2017
LexicalTag NON
ThesaurusID NLM (2018); Constitutive Photomorphogenesis 9 Signalosome
Term UI T000923449
Date05/05/2017
LexicalTag NON
ThesaurusID NLM (2018)

COP9 Signalosome Subunit 1 Narrower

COP9 Signalosome Subunit 2 Narrower

COP9 Signalosome Subunit 3 Narrower

Concept UI: M000631119
Registry Numbers: 0
Terms: COP9 Signalosome Subunit 3 Preferred Term
Term UI T000923455
Date05/05/2017
LexicalTag ACX
ThesaurusID NLM (2018); Signalosome Subunit 3
Term UI T000924283
Date05/12/2017
LexicalTag NON
ThesaurusID NLM (1998); FUSCA Protein 11
Term UI T000924284
Date05/12/2017
LexicalTag ACX
ThesaurusID NLM (2005); Sgn3
Term UI T318534
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (1998)

COP9 Signalosome Subunit 4 Narrower

COP9 Signalosome Subunit 5 Narrower

COP9 Signalosome Subunit 6 Narrower

COP9 Signalosome Subunit 7A Narrower

COP9 Signalosome Subunit 7B Narrower

COP9 Signalosome Subunit 8 Narrower

COP9 Signalosome Complex MeSH Descriptor Data 2025