MeSH Browser

MeSH Heading: Ubiquitin-Specific Peptidase 7
Tree Number(s): D08.811.037.750.750; D08.811.277.656.300.887.875
Unique ID: D000076084
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076084
Scope Note: A ubiquitinyl hydrolase that deubiquitinates several proteins with critical roles in DNA REPAIR, cell growth, and survival, including TUMOR SUPPRESSOR PROTEIN P53; MDM-2 PROTEIN; and PTEN PHOSPHOHYDROLASE. It also stabilizes herpesvirus 1 trans-acting transcriptional protein VMW110 during HSV-1 infection, contributing to its function as a TRANS-ACTIVATOR.
Entry Term(s): HAUSP Protein; Herpesvirus-Associated Ubiquitin-Specific Peptidase; USP7 Protein
Registry Numbers: EC 3.4.19.12
Previous Indexing: Endopeptidases (2002-2017); Ubiquitin Thiolesterase (2008-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/05/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000632175
Registry Numbers: EC 3.4.19.12
Scope Note: A ubiquitinyl hydrolase that deubiquitinates several proteins with critical roles in DNA REPAIR, cell growth, and survival, including TUMOR SUPPRESSOR PROTEIN P53; MDM-2 PROTEIN; and PTEN PHOSPHOHYDROLASE. It also stabilizes herpesvirus 1 trans-acting transcriptional protein VMW110 during HSV-1 infection, contributing to its function as a TRANS-ACTIVATOR.
Terms: Ubiquitin-Specific Peptidase 7 Preferred Term
Term UI T000925311
Date05/24/2017
LexicalTag NON
ThesaurusID NLM (2018); USP7 Protein
Term UI T000925306
Date05/24/2017
LexicalTag ABX
ThesaurusID NLM (2018); HAUSP Protein
Term UI T000925307
Date05/24/2017
LexicalTag ACX
ThesaurusID NLM (2018); Herpesvirus-Associated Ubiquitin-Specific Peptidase
Term UI T000925312
Date05/24/2017
LexicalTag NON
ThesaurusID NLM (2018)

Ubiquitin-Specific Peptidase 7 MeSH Descriptor Data 2025