MeSH Browser

MeSH Heading: Mechanistic Target of Rapamycin Complex 1
Tree Number(s): D05.500.337; D08.811.913.696.620.682.700.931.500; D12.776.476.563.931.500
Unique ID: D000076222
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076222
Scope Note: An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.
Entry Term(s): TOR Complex 1; TORC1; Target of Rapamycin Complex 1; mTORC1; mTORC1 Complex
Public MeSH Note: 2018; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 was indexed under MULTIPROTEIN COMPLEXES and TOR SERINE-THREONINE KINASES 2013-2017
History Note: 2018 (2013)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0579317
Scope Note: An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.
Terms: Mechanistic Target of Rapamycin Complex 1 Preferred Term
Term UI T000925779
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2013); TOR Complex 1
Term UI T000925780
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2013); Target of Rapamycin Complex 1
Term UI T000925781
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2013); mTORC1 Complex
Term UI T000925782
Date05/31/2017
LexicalTag ABX
ThesaurusID NLM (2018); TORC1
Term UI T833709
Date12/03/2012
LexicalTag ACR
ThesaurusID NLM (2013); mTORC1
Term UI T833710
Date12/03/2012
LexicalTag ABB
ThesaurusID NLM (2013)

Mechanistic Target of Rapamycin Complex 1 MeSH Descriptor Data 2024