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Mechanistic Target of Rapamycin Complex 1 MeSH Descriptor Data 2023


MeSH Heading
Mechanistic Target of Rapamycin Complex 1
Tree Number(s)
D05.500.337
D08.811.913.696.620.682.700.931.500
D12.776.476.563.931.500
Unique ID
D000076222
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076222
Scope Note
An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.
Entry Term(s)
TOR Complex 1
TORC1
Target of Rapamycin Complex 1
mTORC1
mTORC1 Complex
Registry Number
EC 2.7.11.1
Public MeSH Note
2018; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 was indexed under MULTIPROTEIN COMPLEXES and TOR SERINE-THREONINE KINASES 2013-2017
History Note
2018 (2013)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/05/21
Mechanistic Target of Rapamycin Complex 1 Preferred
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