MeSH Browser

MeSH Heading: DNA Topoisomerases, Type II
Tree Number(s): D08.811.399.403.741
Unique ID: D004250
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004250
Scope Note: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Entry Term(s): DNA Topoisomerase (ATP-Hydrolysing); DNA Topoisomerase II; DNA Topoisomerase II alpha; DNA Topoisomerase II beta; DNA Type 2 Topoisomerase; TOP2A Protein; TOP2B Protein; Topoisomerase II; Topoisomerase II alpha; Topoisomerase II beta; Type II DNA Topoisomerase
Registry Numbers: EC 5.99.1.3; 0
Previous Indexing: DNA (1966-1977); DNA Replication (1968-1979); DNA, Superhelical (1978-1979); DNA Untwisting Proteins (1978-1979)
Public MeSH Note: 2018; see DNA TOPOISOMERASE (ATP-HYDROLYSING) 1994-2001, see DNA GYRASE 1980-1993; DNA TOPOISOMERASE II ALPHA was indexed under ANTIGENS, NEOPLASM; DNA TOPOSIOMERASES, TYPE II, and DNA-BINDING PROTEINS 2002-2017; and under DNA TOPOISOMERASE (ATP-HYDROLYSING) 1992-2001; DNA TOPOISOMERASE II BETA was indexed under DNA TOPOISOMERASES, TYPE II and DNA-BINDING PROTEINS 2002-2017
History Note: 2018(2002); use DNA GYRASE 1980-1993
Entry Combination: antagonists & inhibitors:Topoisomerase II Inhibitors
Date Established: 1980/01/01
Date of Entry: 1979/05/23
Revision Date: 2017/07/03

Entry Combination: antagonists & inhibitors:Topoisomerase II Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Isomerases [D08.811.399]
    - DNA Topoisomerases [D08.811.399.403]
      - DNA Topoisomerases, Type I [D08.811.399.403.483]
      - DNA Topoisomerases, Type II [D08.811.399.403.741]
        
        DNA Gyrase [D08.811.399.403.741.149]
        
        DNA Topoisomerase IV [D08.811.399.403.741.224]

DNA Topoisomerases, Type II Preferred

Concept UI: M0381050
Registry Numbers: EC 5.99.1.3
Scope Note: DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Terms: DNA Topoisomerases, Type II Preferred Term
Term UI T439349
Date03/15/2001
LexicalTag NON
ThesaurusID NLM (2002); DNA Topoisomerase II
Term UI T012901
Date06/05/1985
LexicalTag NON
ThesaurusID UNK (19XX); Type II DNA Topoisomerase
Term UI T012902
Date06/12/1985
LexicalTag NON
ThesaurusID UNK (19XX); DNA Type 2 Topoisomerase
Term UI T012903
Date10/21/1992
LexicalTag NON
ThesaurusID NLM (1994); DNA Topoisomerase (ATP-Hydrolysing)
Term UI T012904
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1980); Topoisomerase II
Term UI T442624
Date04/12/2001
LexicalTag NON
ThesaurusID NLM (2002)

DNA Topoisomerase II alpha Narrower

DNA Topoisomerase II beta Narrower

DNA Topoisomerases, Type II MeSH Descriptor Data 2025