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DNA Topoisomerase IV MeSH Descriptor Data 2022


MeSH Heading
DNA Topoisomerase IV
Tree Number(s)
D08.811.399.403.741.224
D12.776.097.256
Unique ID
D027101
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D027101
Scope Note
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
Entry Term(s)
Topo IV
Topoisomerase IV
Topoisomerase IV Subunit A
Topoisomerase IV Subunit B
parC Gene Product
parC Gene Product, Topo IV
parC Protein
parE Gene Product
parE Gene Product, Topo IV
parE Protein
Registry Number
EC 5.99.1.-
Previous Indexing
DNA Topoisomerase (1990-1995)
DNA Topoisomerase (ATP-Hydrolysing) (1991-2001)
Public MeSH Note
2002; DNA TOPOISOMERASE IV was indexed under TYPE II DNA TOPOISOMERASE 1991-2001
History Note
2002; use DNA TOPOISOMERASE IV (NM) 1991-2001
Date Established
2002/01/01
Date of Entry
2001/07/25
Revision Date
2010/06/25
DNA Topoisomerase IV Preferred
parC Protein Narrower
parE Protein Narrower
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