MeSH Browser

MeSH Heading: DNA Topoisomerase IV
Tree Number(s): D08.811.399.403.741.224; D12.776.097.256
Unique ID: D027101
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D027101
Scope Note: A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
Entry Term(s): Topo IV; Topoisomerase IV; Topoisomerase IV Subunit A; Topoisomerase IV Subunit B; parC Gene Product; parC Gene Product, Topo IV; parC Protein; parE Gene Product; parE Gene Product, Topo IV; parE Protein
Registry Number: EC 5.99.1.-
Previous Indexing: DNA Topoisomerase (1990-1995); DNA Topoisomerase (ATP-Hydrolysing) (1991-2001)
Public MeSH Note: 2002; DNA TOPOISOMERASE IV was indexed under TYPE II DNA TOPOISOMERASE 1991-2001
History Note: 2002; use DNA TOPOISOMERASE IV (NM) 1991-2001
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2010/06/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0379539
Registry Number: EC 5.99.1.-
Scope Note: One of the two subunits in DNA topoisomerase IV.
Terms: parC Protein Preferred Term
Term UI T211521
LexicalTag NON
ThesaurusID NLM (2002); parC Gene Product, Topo IV
Term UI T437411
Date02/28/2001
LexicalTag NON
ThesaurusID NLM (2002); Topoisomerase IV Subunit A
Term UI T442807
Date04/13/2001
LexicalTag NON
ThesaurusID NLM (2002); parC Gene Product
Term UI T211520
LexicalTag NON
ThesaurusID NLM (2002)

Concept UI: M0210672
Registry Number: EC 5.99.1.-
Scope Note: One of the two subunits in DNA topoisomerase IV.
Terms: parE Protein Preferred Term
Term UI T240677
LexicalTag NON
ThesaurusID NLM (2002); parE Gene Product, Topo IV
Term UI T437419
Date02/28/2001
LexicalTag NON
ThesaurusID NLM (2002); Topoisomerase IV Subunit B
Term UI T442808
Date04/13/2001
LexicalTag NON
ThesaurusID NLM (2002); parE Gene Product
Term UI T240676
LexicalTag NON
ThesaurusID NLM (2002)

DNA Topoisomerase IV MeSH Descriptor Data 2024