MeSH Browser

MeSH Heading: CRISPR-Associated Protein 9
Tree Number(s): D08.811.277.352.355.325.150; D12.776.097.219; D12.776.212.500
Unique ID: D000076987
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076987
Scope Note: An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9.
Entry Term(s): Cas9 Endonuclease; Cas9 Enzyme; Cas9 Protein
Previous Indexing: Bacterial Proteins (2015-2018); Endonucleases (2015-2018)
See Also: CRISPR-Cas Systems; Gene Editing
Public MeSH Note: 2019
History Note: 2019
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2021/07/07

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000638955
Scope Note: An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9.
Terms: CRISPR-Associated Protein 9 Preferred Term
Term UI T000938918
Date01/10/2018
LexicalTag ACX
ThesaurusID NLM (2019); Cas9 Endonuclease
Term UI T000935954
Date11/15/2017
LexicalTag ABX
ThesaurusID NLM (2019); Cas9 Enzyme
Term UI T000935955
Date11/15/2017
LexicalTag ABX
ThesaurusID NLM (2019); Cas9 Protein
Term UI T000935956
Date11/15/2017
LexicalTag ABX
ThesaurusID NLM (2019)

CRISPR-Associated Protein 9 MeSH Descriptor Data 2024