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Flap Endonucleases MeSH Descriptor Data 2023


MeSH Heading
Flap Endonucleases
Tree Number(s)
D08.811.277.352.355.325.350
Unique ID
D045585
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D045585
Scope Note
Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.
Entry Term(s)
FEN-1
Fen1 Protein
Flap Endonuclease
Flap Endonuclease-1
RAD2 Homolog-1 Nuclease
RTH-1 Nuclease
Registry Number
EC 3.1.-
Previous Indexing
Endodeoxyribonucleases (1994-2003)
Public MeSH Note
2004; FLAP ENDONUCLEASES was indexed under ENDODEOYRIBONUCLEASES 1994-2003; FEN1 PROTEIN was indexed under EXODEOXYRIBNUCLEASES 1997-2003; RTH-1 NUCLEASE was indexed under EXODEOXYRIBNUCLEASES 1996-2003
History Note
2004; use FLAP ENDONUCLEASES (NM) 1994-2003; for FEN1 PROTEIN use EXODEOXYRIBONUCLEASE V 1997-2003; for RTH-1 NUCLEASE use EXODEOXYRIBONUCLEASE V 1996-2003
Date Established
2004/01/01
Date of Entry
2003/07/09
Revision Date
2021/06/30
Flap Endonucleases Preferred
Flap Endonuclease-1 Narrower
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