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DNA Restriction Enzymes MeSH Descriptor Data 2022


MeSH Heading
DNA Restriction Enzymes
Tree Number(s)
D08.811.150.280
D08.811.277.352.335.350.300
D08.811.277.352.355.325.300
Unique ID
D004262
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004262
Annotation
DNA restriction enzyme used as a DNA marker: coord probably NIM with GENETIC MARKER (IM)
Scope Note
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Entry Term(s)
DNA Restriction Enzyme
Restriction Endonuclease
Restriction Endonucleases
Registry Number
EC 3.1.21.-
NLM Classification #
QU 136
Previous Indexing
Deoxyribonucleases (1974)
Endonucleases (1974)
See Also
Polymorphism, Restriction Fragment Length
Restriction Mapping
Public MeSH Note
79; was DNA RESTRICTION ENZYME 1978, was DNA RESTRICTION ENZYME see under ENDONUCLEASES 1975-77
Online Note
use DNA RESTRICTION ENZYMES to search DNA RESTRICTION ENZYME l975-89
History Note
79; was DNA RESTRICTION ENZYME 1978, was DNA RESTRICTION ENZYME see under ENDONUCLEASES 1975-77
Date Established
1978/01/01
Date of Entry
1974/11/19
Revision Date
2006/07/05
DNA Restriction Enzymes Preferred
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