- Concept UI
- M0006671
- Scope Note
- Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
- Terms
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DNA Restriction Enzymes
Preferred Term
Term UI
T012957
Date01/01/1999
LexicalTag
ACX
ThesaurusID
NLM (1975)
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DNA Restriction Enzyme
Term UI
T012956
Date05/18/1978
LexicalTag
NON
ThesaurusID
UNK (19XX)
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Restriction Endonuclease
Term UI
T012958
Date05/18/1978
LexicalTag
NON
ThesaurusID
UNK (19XX)
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Restriction Endonucleases
Term UI
T012959
Date05/18/1978
LexicalTag
NON
ThesaurusID
UNK (19XX)