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DNA Topoisomerases, Type II MeSH Descriptor Data 2022


MeSH Heading
DNA Topoisomerases, Type II
Tree Number(s)
D08.811.399.403.741
Unique ID
D004250
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D004250
Scope Note
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex.
Entry Term(s)
DNA Topoisomerase (ATP-Hydrolysing)
DNA Topoisomerase II
DNA Topoisomerase II alpha
DNA Topoisomerase II beta
DNA Type 2 Topoisomerase
TOP2A Protein
TOP2B Protein
Topoisomerase II
Topoisomerase II alpha
Topoisomerase II beta
Type II DNA Topoisomerase
Registry Number
EC 5.99.1.3
Previous Indexing
DNA (1966-1977)
DNA Replication (1968-1979)
DNA Untwisting Proteins (1978-1979)
DNA, Superhelical (1978-1979)
Public MeSH Note
2018; see DNA TOPOISOMERASE (ATP-HYDROLYSING) 1994-2001, see DNA GYRASE 1980-1993; DNA TOPOISOMERASE II ALPHA was indexed under ANTIGENS, NEOPLASM; DNA TOPOSIOMERASES, TYPE II, and DNA-BINDING PROTEINS 2002-2017; and under DNA TOPOISOMERASE (ATP-HYDROLYSING) 1992-2001; DNA TOPOISOMERASE II BETA was indexed under DNA TOPOISOMERASES, TYPE II and DNA-BINDING PROTEINS 2002-2017
History Note
2018(2002); use DNA GYRASE 1980-1993
Entry Combination
antagonists & inhibitors:Topoisomerase II Inhibitors
Date Established
1980/01/01
Date of Entry
1979/05/23
Revision Date
2017/07/03
DNA Topoisomerases, Type II Preferred
DNA Topoisomerase II beta Narrower
DNA Topoisomerase II alpha Narrower
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