MeSH Browser

MeSH Heading: Heparin Cofactor II
Tree Number(s): D12.644.861.060.750; D12.776.124.790.106.450; D12.776.377.715.085.450; D12.776.872.060.750
Unique ID: D015844
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015844
Scope Note: A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.
Entry Term(s): Heparin Co-Factor II; Heparin Cofactor 2; Leuserpin 2; Protease Inhibitor Leuserpin 2; Serpin D1
Pharm Action: Antithrombins
Serine Proteinase Inhibitors
Registry Number: 81604-65-1
CAS Type 1 Name: Heparin cofactor II
Previous Indexing: Antithrombins (1966-1989); Glycoproteins (1966-1989)
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2015/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024263
Registry Number: 81604-65-1
Scope Note: A sulfated plasma protein with a MW of approximately 66kDa that resembles ANTITHROMBIN III. The protein is an inhibitor of thrombin in plasma and is activated by dermatan sulfate or heparin. It is a member of the serpin superfamily.
Terms: Heparin Cofactor II Preferred Term
Term UI T046975
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Serpin D1
Term UI T734785
Date02/09/2009
LexicalTag NON
ThesaurusID NLM (2010); Leuserpin 2
Term UI T768210
Date03/30/2010
LexicalTag NON
ThesaurusID NLM (2011); Heparin Co-Factor II
Term UI T046976
Date04/25/1989
LexicalTag NON
ThesaurusID NLM (1990); Heparin Cofactor 2
Term UI T734783
Date02/09/2009
LexicalTag NON
ThesaurusID NLM (2010); Protease Inhibitor Leuserpin 2
Term UI T734784
Date02/09/2009
LexicalTag NON
ThesaurusID NLM (2010)

Heparin Cofactor II MeSH Descriptor Data 2024