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Hirudins MeSH Descriptor Data 2022


MeSH Heading
Hirudins
Tree Number(s)
D12.644.861.060.875
D12.776.872.060.875
Unique ID
D006629
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D006629
Scope Note
Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.
Entry Term(s)
Hirudin
Pharm Action
Antithrombins
Fibrinolytic Agents
Registry Number
0
Related Numbers
8001-27-2
Public MeSH Note
2005; see HIRUDIN 1963-2004
History Note
2005(1963)
Entry Combination
therapeutic use:Hirudin Therapy
Date Established
2005/01/01
Date of Entry
1999/01/01
Revision Date
2015/06/22
Hirudins Preferred
Hirudin Narrower
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