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Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Entry Term(s)
Class I Histone Deacetylases
Class II Histone Deacetylases
HDAC Proteins
Histone Deacetylase
Histone Deacetylase Complexes
Registry Numbers
EC 3.5.1.98
0
EC 3.5.1.98
EC 3.5.1.98
Related Numbers
EC 3.5.1.98
Previous Indexing
Acetic Acids (1971-1974)
Amidohydrolases (1971-1974)
Histones (1971-1974)
Public MeSH Note
2003; see HISTONE DEACETYLASE 1991-2002; see AMIDOHYDROLASES 1975-1990
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.