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Leukemia Inhibitory Factor Receptor alpha Subunit MeSH Descriptor Data 2022


MeSH Heading
Leukemia Inhibitory Factor Receptor alpha Subunit
Tree Number(s)
D12.776.543.750.705.852.583.750
D12.776.543.750.750.400.550.250.750
Unique ID
D053680
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D053680
Scope Note
A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Entry Term(s)
Antigens, CD118
CD118 Antigen
CD118 Antigens
LIF Receptor alpha Subunit
Registry Number
0
Public MeSH Note
2007
History Note
2007
Date Established
2007/01/01
Date of Entry
2006/07/05
Revision Date
2017/05/24
Leukemia Inhibitory Factor Receptor alpha Subunit Preferred
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