MeSH Browser

MeSH Heading: Leukemia Inhibitory Factor Receptor alpha Subunit
Tree Number(s): D12.776.543.750.705.852.583.750; D12.776.543.750.750.400.550.250.750
Unique ID: D053680
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053680
Scope Note: A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Entry Term(s): Antigens, CD118; CD118 Antigen; CD118 Antigens; LIF Receptor alpha Subunit
Public MeSH Note: 2007
History Note: 2007
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0495573
Scope Note: A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.
Terms: Leukemia Inhibitory Factor Receptor alpha Subunit Preferred Term
Term UI T667562
Date03/03/2006
LexicalTag NON
ThesaurusID NLM (2007); Antigens, CD118
Term UI T666283
Date02/14/2006
LexicalTag ABX
ThesaurusID NLM (2007); CD118 Antigens
Term UI T666284
Date02/14/2006
LexicalTag ABX
ThesaurusID NLM (2007); CD118 Antigen
Term UI T666285
Date02/14/2006
LexicalTag ABX
ThesaurusID NLM (2007); LIF Receptor alpha Subunit
Term UI T668479
Date03/14/2006
LexicalTag ABX
ThesaurusID NLM (2007)

Leukemia Inhibitory Factor Receptor alpha Subunit MeSH Descriptor Data 2024