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MAP Kinase Signaling System MeSH Descriptor Data 2025


MeSH Heading
MAP Kinase Signaling System
Tree Number(s)
G02.111.820.560
G03.493.560
G04.835.560
Unique ID
D020935
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020935
Scope Note
An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Entry Term(s)
ERK Pathway
ERK Signal Tranduction Pathway
ERK1 and ERK2 Pathway
ERK1-2 Pathway
JNK Pathway
JNK Signaling Pathway
MAP Kinase Cascade
MAP Kinase Module
MAP Kinase Modules
MAP Kinase Signaling Cascade
MAP Kinase Signaling Cascades
MAP Kinase Signaling Pathway
MAP Kinase Signaling Pathways
MEK-ERK Pathway
p38 Kinase Pathway
p38 Kinase Signaling Pathway
Previous Indexing
Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1999)
Protein Kinases (1989-1999)
Protein-Serine-Threonine Kinases (1993-1999)
Protein-Tyrosine Kinase (1989-1999)
See Also
MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Public MeSH Note
2000
History Note
2000
Date Established
2000/01/01
Date of Entry
1999/11/05
Revision Date
2022/06/14
MAP Kinase Signaling System Preferred
MAP Kinase Cascade Narrower
MAP Kinase Signaling Pathways Related
ERK1-2 Pathway Related
ERK Signal Tranduction Pathway Narrower
MEK-ERK Pathway Narrower
JNK Pathway Narrower
p38 Kinase Pathway Narrower
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