MeSH Browser

MeSH Heading: Ribosomal Protein S6 Kinases, 90-kDa
Tree Number(s): D08.811.913.696.620.682.700.862.500; D12.776.476.563.862.500
Unique ID: D038744
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D038744
Scope Note: A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
Entry Term(s): MAP-Kinase-Activated Kinase 1; MAP-Kinase-Activated Protein Kinase 1; MAPKAP Kinase-1; MAPKAP-K1; MAPKAPK1; Ribosomal Protein S6 Kinase, 90-kDa; p90 Ribosomal S6 Kinase; p90(rsk); pp90(rsk)
Registry Numbers: EC 2.7.11.1
Previous Indexing: Protein-Serine-Threonine Kinases (1993-1997); Ribosomal Protein S6 Kinase (1998-2002)
Public MeSH Note: 2005; see RIBOSOMAL PROTEIN S6 KINASES, 90KD 2003-2004; MAP-KINASE-ACTIVATED KINASE 1 (now RIBOSOMAL PROTEIN S6 KINASES, 90KDa) was indexed under RIBOSOMAL PROTEIN S6 KINASE 1993-2002; for PP90(RSK) & PP90(RSK) see RIBOSOMAL PROTEIN S6 KINASE 1998-2002
History Note: 2005(2002); for PP90(RSK) & PP90(RSK) use RIBOSOMAL PROTEIN S6 KINASES 1998-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2021/06/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
        
        Ribosomal Protein S6 Kinases, 70-kDa [D08.811.913.696.620.682.700.862.249]
        
        Ribosomal Protein S6 Kinases, 90-kDa [D08.811.913.696.620.682.700.862.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Ribosomal Protein S6 Kinases [D12.776.476.563.862]
        
        Ribosomal Protein S6 Kinases, 70-kDa [D12.776.476.563.862.249]
        
        Ribosomal Protein S6 Kinases, 90-kDa [D12.776.476.563.862.500]

Ribosomal Protein S6 Kinases, 90-kDa Preferred

Concept UI: M0223389
Registry Numbers: EC 2.7.11.1
Scope Note: A family of ribosomal protein S6 kinases that are structurally distinguished from RIBOSOMAL PROTEIN S6 KINASES, 70-KDA by their apparent molecular size and the fact they contain two functional kinase domains. Although considered RIBOSOMAL PROTEIN S6 KINASES, members of this family are activated via the MAP KINASE SIGNALING SYSTEM and have been shown to act on a diverse array of substrates that are involved in cellular regulation such as RIBOSOMAL PROTEIN S6 and CAMP RESPONSE ELEMENT-BINDING PROTEIN.
Terms: Ribosomal Protein S6 Kinases, 90-kDa Preferred Term
Term UI T485316
Date03/12/2002
LexicalTag NON
ThesaurusID NLM (2003); MAPKAP Kinase-1
Term UI T253395
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); MAPKAPK1
Term UI T253396
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); MAP-Kinase-Activated Kinase 1
Term UI T253397
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); Ribosomal Protein S6 Kinase, 90-kDa
Term UI T485044
Date03/08/2002
LexicalTag ACX
ThesaurusID NLM (2003); MAP-Kinase-Activated Protein Kinase 1
Term UI T253394
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); MAPKAP-K1
Term UI T485046
Date03/08/2002
LexicalTag ACR
ThesaurusID NLM (2003); pp90(rsk)
Term UI T059235
Date02/14/1997
LexicalTag ACR
ThesaurusID NLM (1998); p90(rsk)
Term UI T059241
Date02/14/1997
LexicalTag ACR
ThesaurusID NLM (1998); p90 Ribosomal S6 Kinase
Term UI T485045
Date03/08/2002
LexicalTag ACX
ThesaurusID NLM (2003)

Ribosomal Protein S6 Kinases, 90-kDa MeSH Descriptor Data 2025