MeSH Browser

MeSH Heading: Copper-Transporting ATPases
Tree Number(s): D08.811.277.040.025.314.500; D12.776.157.530.450.250.578.750; D12.776.157.530.813.500; D12.776.543.585.450.250.578.750; D12.776.543.585.813.500
Unique ID: D000073840
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000073840
Scope Note: P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
Entry Term(s): ATP7A Protein; ATP7B Cu-Binding P Type ATPase; ATPase Copper Transporting alpha; ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease); Copper Pump 1; Copper-Transporting ATPase; Copper-Transporting ATPase 1; Copper-Transporting ATPase 2; Copper-Transporting Adenosine Triphosphatases; Cu(+)-Transporting ATPases; Cu-Transporting ATPases; Menkes Disease-Associated Protein; PINA Enzyme; Pineal Night-Specific ATPase; Wilson Disease Cu-Binding P Type ATPase; Wilson Disease Protein
Registry Number: EC 7.2.2.8
Related Numbers: EC 3.6.3.54
See Also: Hepatolenticular Degeneration; Menkes Kinky Hair Syndrome
Public MeSH Note: 2018; COPPER-TRANSPORTING ATPASES was indexed under ADENOSINE TRIPHOSPHATASES and CATION TRANSPORT PROTEINS 1994-2017
History Note: 2018 (1994)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2019/04/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Acid Anhydride Hydrolases [D08.811.277.040]
      - Adenosine Triphosphatases [D08.811.277.040.025]
        
        P-type ATPases [D08.811.277.040.025.314]
        
        Calcium-Transporting ATPases [D08.811.277.040.025.314.250]
        
        Copper-Transporting ATPases [D08.811.277.040.025.314.500]
        
        H(+)-K(+)-Exchanging ATPase [D08.811.277.040.025.314.625]
        
        Sodium-Potassium-Exchanging ATPase [D08.811.277.040.025.314.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Cation Transport Proteins [D12.776.157.530.450.250]
        
        Copper Transport Proteins [D12.776.157.530.450.250.578]
        
        Copper-Transporting ATPases [D12.776.157.530.450.250.578.750]
        
        SLC31 Proteins [D12.776.157.530.450.250.578.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - P-type ATPases [D12.776.157.530.813]
        
        Calcium-Transporting ATPases [D12.776.157.530.813.250]
        
        Copper-Transporting ATPases [D12.776.157.530.813.500]
        
        H(+)-K(+)-Exchanging ATPase [D12.776.157.530.813.625]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.157.530.813.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Cation Transport Proteins [D12.776.543.585.450.250]
        
        Copper Transport Proteins [D12.776.543.585.450.250.578]
        
        Copper-Transporting ATPases [D12.776.543.585.450.250.578.750]
        
        SLC31 Proteins [D12.776.543.585.450.250.578.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - P-type ATPases [D12.776.543.585.813]
        
        Calcium-Transporting ATPases [D12.776.543.585.813.250]
        
        Copper-Transporting ATPases [D12.776.543.585.813.500]
        
        H(+)-K(+)-Exchanging ATPase [D12.776.543.585.813.625]
        
        Sodium-Potassium-Exchanging ATPase [D12.776.543.585.813.750]

Copper-Transporting ATPases Preferred

Concept UI: M000624072
Registry Number: EC 7.2.2.8
Related Numbers: EC 3.6.3.54
Scope Note: P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
Terms: Copper-Transporting ATPases Preferred Term
Term UI T000949196
Date12/05/2018
LexicalTag ABX
ThesaurusID NLM (2005); Cu-Transporting ATPases
Term UI T000949200
Date12/05/2018
LexicalTag ABX
ThesaurusID NLM (2018); Cu(+)-Transporting ATPases
Term UI T000949199
Date12/05/2018
LexicalTag ABX
ThesaurusID NLM (2018); Copper-Transporting ATPase
Term UI T000949197
Date12/05/2018
LexicalTag ABX
ThesaurusID NLM (1994); Copper-Transporting Adenosine Triphosphatases
Term UI T000949198
Date12/05/2018
LexicalTag NON
ThesaurusID NLM (2018)

Wilson Disease Protein Narrower

Copper-Transporting ATPase 1 Narrower

Concept UI: M000624522
Registry Number: 0
Terms: Copper-Transporting ATPase 1 Preferred Term
Term UI T000949201
Date12/05/2018
LexicalTag ABX
ThesaurusID NLM (2018); Copper Pump 1
Term UI T000912635
Date12/07/2016
LexicalTag NON
ThesaurusID NLM (2018); ATPase Copper Transporting alpha
Term UI T000912633
Date12/07/2016
LexicalTag ABX
ThesaurusID NLM (2018); Menkes Disease-Associated Protein
Term UI T000949202
Date12/05/2018
LexicalTag NON
ThesaurusID NLM (2018); ATP7A Protein
Term UI T000912631
Date12/07/2016
LexicalTag ABX
ThesaurusID NLM (2018)

Pineal Night-Specific ATPase Narrower

Copper-Transporting ATPases MeSH Descriptor Data 2024