- Concept UI
- M000623906
- Registry Numbers
- EC 3.6.3.-
- Scope Note
- A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.
- Terms
-
P-type ATPases
Preferred Term
Term UI
T000912036
Date11/22/2016
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
P-type ATPase
Term UI
T001008739
Date02/27/2020
LexicalTag
NON
ThesaurusID
NLM (2021)
-
P-type Adenosine Triphosphatase
Term UI
T001008740
Date02/27/2020
LexicalTag
NON
ThesaurusID
NLM (2021)
-
Phosphorylation-type Adenosine Triphosphatases
Term UI
T000912629
Date12/07/2016
LexicalTag
NON
ThesaurusID
NLM (2018)
-
E1-E2 ATPases
Term UI
T000912037
Date11/22/2016
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
P-type Adenosine Triphosphatases
Term UI
T000912181
Date11/28/2016
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
Phosphorylation-type ATPases
Term UI
T000912625
Date12/07/2016
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
E1-E2 ATPase
Term UI
T001090125
Date10/15/2020
LexicalTag
NON
ThesaurusID
NLM (2022)
-
P Type Atpase
Term UI
T001089377
Date10/05/2020
LexicalTag
NON
ThesaurusID
NLM (2022)