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Niemann-Pick C1 Protein MeSH Descriptor Data 2022


MeSH Heading
Niemann-Pick C1 Protein
Tree Number(s)
D12.776.157.530.594
D12.776.543.585.594
D12.776.543.750.058.250
D12.776.543.750.830.235
D12.776.624.776.633.250
Unique ID
D000077296
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077296
Scope Note
A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.
Entry Term(s)
NPC1 Protein
Registry Number
0
Previous Indexing
Carrier Proteins (1997-2018)
Membrane Glycoproteins (1997-2018)
Public MeSH Note
2019
History Note
2019
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/02/28
Niemann-Pick C1 Protein Preferred
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