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Copper-Transporting ATPases MeSH Descriptor Data 2022


MeSH Heading
Copper-Transporting ATPases
Tree Number(s)
D08.811.277.040.025.314.500
D12.776.157.530.450.250.578.750
D12.776.157.530.813.500
D12.776.543.585.450.250.578.750
D12.776.543.585.813.500
Unique ID
D000073840
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000073840
Scope Note
P-type ATPases which transport copper ions across membranes in prokaryotic and eukaryotic cells. They possess a conserved CYSTEINE-HISTIDINE-SERINE (CPx) amino acid motif within their transmembrane helices that functions in cation translocation and catalytic activation, and an N-terminal copper-binding CxxC motif that regulates enzyme activity. They play essential roles in intracellular copper homeostasis through regulating the uptake, efflux and storage of copper ions, and in cuproprotein biosynthesis.
Entry Term(s)
ATP7A Protein
ATP7B Cu-Binding P Type ATPase
ATPase Copper Transporting alpha
ATPase, Cu++ Transporting, beta Polypeptide (Wilson Disease)
Copper Pump 1
Copper-Transporting ATPase
Copper-Transporting ATPase 1
Copper-Transporting ATPase 2
Copper-Transporting Adenosine Triphosphatases
Cu(+)-Transporting ATPases
Cu-Transporting ATPases
Menkes Disease-Associated Protein
PINA Enzyme
Pineal Night-Specific ATPase
Wilson Disease Cu-Binding P Type ATPase
Wilson Disease Protein
Registry Number
EC 7.2.2.8
Related Numbers
EC 3.6.3.54
See Also
Hepatolenticular Degeneration
Menkes Kinky Hair Syndrome
Public MeSH Note
2018; COPPER-TRANSPORTING ATPASES was indexed under ADENOSINE TRIPHOSPHATASES and CATION TRANSPORT PROTEINS 1994-2017
History Note
2018 (1994)
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2019/04/29
Copper-Transporting ATPases Preferred
Wilson Disease Protein Narrower
Copper-Transporting ATPase 1 Narrower
Pineal Night-Specific ATPase Narrower
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