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Lovastatin MeSH Descriptor Data 2022


MeSH Heading
Lovastatin
Tree Number(s)
D02.455.426.559.847.638.400
D04.615.638.400
Unique ID
D008148
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D008148
Scope Note
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
Entry Term(s)
6-Methylcompactin
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha-Isomer
MK-803
Mevacor
Mevinolin
Monacolin K
Pharm Action
Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registry Number
9LHU78OQFD
Related Numbers
75330-75-5
79902-41-3
79952-44-6
CAS Type 1 Name
Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-
Previous Indexing
Anticholesteremic Agents (1966-1987)
Hydroxymethylglutaryl CoA Reductases/antagonists & inhibitors (1977-1987)
Naphthalenes (1966-1987)
Public MeSH Note
88; MONACOLIN K was indexed under NAPHTHALENES 1981-98 & ANTIBIOTICS 1980
History Note
88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
Date Established
1988/01/01
Date of Entry
1987/05/04
Revision Date
2015/06/23
Lovastatin Preferred
MK-803 Narrower
Mevacor Narrower
Lovastatin, (1 alpha(S*))-Isomer Narrower
Lovastatin, 1 alpha-Isomer Narrower
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