MeSH Browser

MeSH Heading: Adapalene
Tree Number(s): D02.455.326.271.665.202.495.150; D02.455.426.392.368.367.379.249.700.001; D02.455.426.559.847.638.090; D02.455.849.131.495.150; D04.615.638.090; D23.767.261.700.150
Unique ID: D000068816
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000068816
Scope Note: A naphthalene derivative that has specificity for RETINOIC ACID RECEPTORS. It is used as a DERMATOLOGIC AGENT for the treatment of ACNE.
Entry Term(s): 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid; Adaferin; Differin; Differine
Pharm Action: Anti-Inflammatory Agents, Non-Steroidal
Dermatologic Agents
Registry Numbers: 1L4806J2QF; 0
Related Numbers: 106685-40-9
Public MeSH Note: 2016; ADAPALENE was indexed under NAPHTHALENES 1990-2015
History Note: 2016 (1990)
Date Introduced: 2016/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Acyclic [D02.455.326]
    - Alkenes [D02.455.326.271]
      - Polyenes [D02.455.326.271.665]
        
        Carotenoids [D02.455.326.271.665.202]
        
        Retinoids [D02.455.326.271.665.202.495]
        
        Acitretin [D02.455.326.271.665.202.495.050]
        
        Adapalene [D02.455.326.271.665.202.495.150]
        
        Bexarotene [D02.455.326.271.665.202.495.200]
        
        Etretinate [D02.455.326.271.665.202.495.250]
        
        Fenretinide [D02.455.326.271.665.202.495.270]
        
        Isotretinoin [D02.455.326.271.665.202.495.325]
        
        Retinaldehyde [D02.455.326.271.665.202.495.690]
        
        Retinyl Esters [D02.455.326.271.665.202.495.754]
        
        Vitamin A [D02.455.326.271.665.202.495.818]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Alicyclic [D02.455.426.392]
      - Cycloparaffins [D02.455.426.392.368]
        
        Cyclohexanes [D02.455.426.392.368.367]
        
        Cyclohexenes [D02.455.426.392.368.367.379]
        
        Carotenoids [D02.455.426.392.368.367.379.249]
        
        Retinoids [D02.455.426.392.368.367.379.249.700]
        
        Adapalene [D02.455.426.392.368.367.379.249.700.001]
        
        Bexarotene [D02.455.426.392.368.367.379.249.700.136]
        
        Fenretinide [D02.455.426.392.368.367.379.249.700.270]
        
        Isotretinoin [D02.455.426.392.368.367.379.249.700.325]
        
        Retinaldehyde [D02.455.426.392.368.367.379.249.700.690]
        
        Retinyl Esters [D02.455.426.392.368.367.379.249.700.775]
        
        Vitamin A [D02.455.426.392.368.367.379.249.700.860]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Hydrocarbons, Cyclic [D02.455.426]
    - Hydrocarbons, Aromatic [D02.455.426.559]
      - Polycyclic Aromatic Hydrocarbons [D02.455.426.559.847]
        
        Naphthalenes [D02.455.426.559.847.638]
        
        Acenaphthenes [D02.455.426.559.847.638.059]
        
        Adapalene [D02.455.426.559.847.638.090]
        
        Adapalene, Benzoyl Peroxide Drug Combination [D02.455.426.559.847.638.090.500]
        
        Bunaftine [D02.455.426.559.847.638.120]
        
        Carbaryl [D02.455.426.559.847.638.162]
        
        Cinacalcet [D02.455.426.559.847.638.183]
        
        Dansyl Compounds [D02.455.426.559.847.638.204]
        
        Lovastatin [D02.455.426.559.847.638.400]
        
        Naphthaleneacetic Acids [D02.455.426.559.847.638.472]
        
        Naphthalenesulfonates [D02.455.426.559.847.638.555]
        
        Naphthols [D02.455.426.559.847.638.638]
        
        Naphthoquinones [D02.455.426.559.847.638.721]
        
        1-Naphthylamine [D02.455.426.559.847.638.845]
        
        2-Naphthylamine [D02.455.426.559.847.638.850]
        
        1-Naphthylisothiocyanate [D02.455.426.559.847.638.870]
        
        Naphthylvinylpyridine [D02.455.426.559.847.638.900]
        
        Pravastatin [D02.455.426.559.847.638.930]
        
        Propranolol [D02.455.426.559.847.638.945]
        
        Terbinafine [D02.455.426.559.847.638.953]
        
        Tetrahydronaphthalenes [D02.455.426.559.847.638.960]
        
        Tolnaftate [D02.455.426.559.847.638.975]

Organic Chemicals [D02]
- Hydrocarbons [D02.455]
  - Terpenes [D02.455.849]
    - Carotenoids [D02.455.849.131]
      - Retinoids [D02.455.849.131.495]
        
        Acitretin [D02.455.849.131.495.050]
        
        Adapalene [D02.455.849.131.495.150]
        
        Bexarotene [D02.455.849.131.495.200]
        
        Etretinate [D02.455.849.131.495.250]
        
        Fenretinide [D02.455.849.131.495.270]
        
        Isotretinoin [D02.455.849.131.495.325]
        
        Retinaldehyde [D02.455.849.131.495.690]
        
        Retinyl Esters [D02.455.849.131.495.754]
        
        Vitamin A [D02.455.849.131.495.818]

Polycyclic Compounds [D04]
- Polycyclic Aromatic Hydrocarbons [D04.615]
  - Naphthalenes [D04.615.638]

Biological Factors [D23]
- Pigments, Biological [D23.767]
  - Carotenoids [D23.767.261]
    - Retinoids [D23.767.261.700]

Adapalene Preferred

Differin Narrower

Adaferin Narrower

Adapalene MeSH Descriptor Data 2026