MeSH Browser

MeSH Heading: Everolimus
Tree Number(s): D02.540.505.760.500
Unique ID: D000068338
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000068338
Scope Note: A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT.
Entry Term(s): 40-O-(2-hydroxyethyl)-rapamycin; Afinitor; Certican; RAD 001; RAD001; SDZ RAD; SDZ-RAD; Zortress
Pharm Action: Immunosuppressive Agents
MTOR Inhibitors
Public MeSH Note: 2016; EVEROLIMUS was indexed under SIROLIMUS 1998-2015; and under POLYENES 1997-1998
History Note: 2016 (1997)
Date Established: 2016/01/01
Date of Entry: 2015/07/01
Revision Date: 2022/07/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M000602394
Scope Note: A derivative of sirolimus and an inhibitor of TOR SERINE-THREONINE KINASES. It is used to prevent GRAFT REJECTION in heart and kidney transplant patients by blocking cell proliferation signals. It is also an ANTINEOPLASTIC AGENT.
Terms: Everolimus Preferred Term
Term UI T000875190
Date02/12/2015
LexicalTag NON
ThesaurusID NLM (2016); 40-O-(2-hydroxyethyl)-rapamycin
Term UI T308863
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (1997); SDZ RAD
Term UI T308864
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (1997); SDZ-RAD
Term UI T544057
Date06/23/2003
LexicalTag NON
ThesaurusID NLM (2003)

Everolimus MeSH Descriptor Data 2024