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Nogo Proteins MeSH Descriptor Data 2022

MeSH Heading
Nogo Proteins
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Entry Term(s)
NI-220 Protein
NI-250 Protein
NI-35 Protein
Neurite Growth Inhibitor 35-350
Nogo Protein
Nogo-66 Protein
Nogo-A Protein
Nogo-B Protein
Nogo-C Protein
Reticulon 4-B Protein
Reticulon-4 Protein
Registry Number
Public MeSH Note
2017; NOGO PROTEIN was indexed under MYELIN PROTEINS 2000-2016
History Note
2017 (2000)
Date Established
Date of Entry
Revision Date
Nogo Proteins Preferred
Nogo-C Protein Narrower
Neurite Growth Inhibitor 35-350 Narrower
Nogo-A Protein Narrower
NI-35 Protein Narrower
Nogo-B Protein Narrower
Nogo-66 Protein Narrower
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