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Nogo Proteins MeSH Descriptor Data 2022


MeSH Heading
Nogo Proteins
Tree Number(s)
D12.776.543.620.738
D12.776.631.580.738
Unique ID
D000070798
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000070798
Scope Note
Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Entry Term(s)
NI-220 Protein
NI-250 Protein
NI-35 Protein
NI-35-250
Neurite Growth Inhibitor 35-350
Nogo Protein
Nogo-66 Protein
Nogo-A Protein
Nogo-B Protein
Nogo-C Protein
Reticulon 4-B Protein
Reticulon-4 Protein
Registry Number
0
Public MeSH Note
2017; NOGO PROTEIN was indexed under MYELIN PROTEINS 2000-2016
History Note
2017 (2000)
Date Established
2017/01/01
Date of Entry
2016/07/11
Revision Date
2016/07/11
Nogo Proteins Preferred
Nogo-C Protein Narrower
Neurite Growth Inhibitor 35-350 Narrower
Nogo-A Protein Narrower
NI-35 Protein Narrower
Nogo-B Protein Narrower
Nogo-66 Protein Narrower
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