MeSH Browser

MeSH Heading: ADAMTS5 Protein
Tree Number(s): D08.811.277.656.675.374.102.500.875; D09.400.430.500.500.875; D12.776.395.033.500.875; D12.776.860.300.085.875
Unique ID: D000071116
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071116
Scope Note: An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.
Entry Term(s): A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein; ADAMTS-5 Protein; ADAMTS11 Protein; ADAMTS5 Protease; Aggrecanase-2
Registry Number: EC 3.4.24.-
Previous Indexing: ADAM Proteins (2006-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/02/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613164
Registry Number: EC 3.4.24.-
Scope Note: An ADAMTS protease that contains two C-terminal thrombospondin (TS) motifs. It functions primarily as an aggrecanase, cleaving AGGRECAN in CARTILAGE, and may be involved in the destruction of aggrecan in ARTHRITIS.
Terms: ADAMTS5 Protein Preferred Term
Term UI T000892849
Date12/29/2015
LexicalTag NON
ThesaurusID NLM (2017); A Disintegrin And Metalloproteinase With Thrombospondin Motifs 5 Protein
Term UI T000894714
Date02/05/2016
LexicalTag NON
ThesaurusID NLM (2017); ADAMTS11 Protein
Term UI T000892853
Date12/29/2015
LexicalTag NON
ThesaurusID NLM (2017); Aggrecanase-2
Term UI T000892854
Date12/29/2015
LexicalTag NON
ThesaurusID NLM (2017); ADAMTS-5 Protein
Term UI T000892850
Date12/29/2015
LexicalTag ABX
ThesaurusID NLM (2017); ADAMTS5 Protease
Term UI T000892851
Date12/29/2015
LexicalTag NON
ThesaurusID NLM (2017)

ADAMTS5 Protein MeSH Descriptor Data 2024