MeSH Browser

MeSH Heading: ADAMTS4 Protein
Tree Number(s): D08.811.277.656.675.374.102.500.844; D09.400.430.500.500.844; D12.776.395.033.500.844; D12.776.860.300.085.844
Unique ID: D000071121
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071121
Scope Note: An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.
Entry Term(s): A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein; ADAMTS-4 Protein; Aggrecanase-1
Registry Numbers: EC 3.4.24.82
Public MeSH Note: 2017; ADAMTS4 PROTEIN was indexed under PROCOLLAGEN N-ENDOPEPTIDASE and ADAM PROTEINS 2006-2016; and under METALLOENDOPEPTIDASES 1999-2005
History Note: 2017 (1999)
Date Established: 2017/01/01
Date of Entry: 2016/07/06
Revision Date: 2016/02/26

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613177
Registry Numbers: EC 3.4.24.82
Scope Note: An ADAMTS protease similar to ADAMTS5 PROTEIN. It contains a single C-terminal thrombospondin (TS) motif and cleaves AGGRECAN in CARTILAGE. It may also be involved in the destruction of aggrecan in ARTHRITIS.
Terms: ADAMTS4 Protein Preferred Term
Term UI T000892892
Date12/29/2015
LexicalTag ACX
ThesaurusID NLM (2017); ADAMTS-4 Protein
Term UI T000892893
Date12/29/2015
LexicalTag ACX
ThesaurusID NLM (2017); Aggrecanase-1
Term UI T000892894
Date12/29/2015
LexicalTag NON
ThesaurusID NLM (1999); A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 Protein
Term UI T000894715
Date02/05/2016
LexicalTag NON
ThesaurusID NLM (2017)

ADAMTS4 Protein MeSH Descriptor Data 2024