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ETS Motif MeSH Descriptor Data 2023


MeSH Heading
ETS Motif
Tree Number(s)
G02.111.570.820.709.275.500.360.360.500
Unique ID
D000071419
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071419
Scope Note
A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.
Entry Term(s)
ETS Domain
Helix-Turn-Helix, ETS-Type Domain Containing
Previous Indexing
Amino Acid Sequence (1990-2016)
Proto-Oncogene Proteins (1990-2016)
Transcription Factors (1990-2016)
See Also
Proto-Oncogene Protein c-ets-1
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/05/09
ETS Motif Preferred
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