MeSH Browser

MeSH Heading: ETS Motif
Tree Number(s): G02.111.570.820.709.275.500.360.360.500
Unique ID: D000071419
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071419
Scope Note: A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.
Entry Term(s): ETS Domain; Helix-Turn-Helix, ETS-Type Domain Containing
Previous Indexing: Amino Acid Sequence (1990-2016); Proto-Oncogene Proteins (1990-2016); Transcription Factors (1990-2016)
See Also: Proto-Oncogene Protein c-ets-1
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/05/09

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M000614527
Scope Note: A helix-turn-helix motif characterized by three alpha-helices and four-stranded beta-sheets arranged in the order alpha1-beta1-beta2-alpha2-alpha3-beta3-beta4. The third alpha-helix contacts the major groove of DNA. The ETS motif and the flanking amino acid sequences of Ets proteins influence the binding affinity, and the alteration of a single amino acid in the Ets domain can change its DNA binding specificity.
Terms: ETS Motif Preferred Term
Term UI T000895132
Date02/12/2016
LexicalTag ABX
ThesaurusID NLM (2017); Helix-Turn-Helix, ETS-Type Domain Containing
Term UI T000895135
Date02/12/2016
LexicalTag NON
ThesaurusID NLM (2017); ETS Domain
Term UI T000895133
Date02/12/2016
LexicalTag ABX
ThesaurusID NLM (2017)

ETS Motif MeSH Descriptor Data 2024