MeSH Browser

MeSH Heading: Helix-Loop-Helix Motifs
Tree Number(s): G02.111.570.820.709.275.500.360
Unique ID: D018257
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018257
Annotation: do not confuse with HELIX-TURN-HELIX MOTIFS
Scope Note: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical loop segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
Entry Term(s): HLH Motifs; Helix-Loop-Helix Domain; Helix-Loop-Helix Domains; Helix-Loop-Helix Motif; Motifs, Helix-Loop-Helix
Previous Indexing: Amino Acid Sequence (1989-1993)
Public MeSH Note: 94
History Note: 94
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2016/05/27

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Amino Acid Motifs [G02.111.570.820.709.275.500]
        
        Ankyrin Repeat [G02.111.570.820.709.275.500.030]
        
        AT-Hook Motifs [G02.111.570.820.709.275.500.050]
        
        Cystine Knot Motifs [G02.111.570.820.709.275.500.127]
        
        F-Box Motifs [G02.111.570.820.709.275.500.205]
        
        Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]
        
        EF Hand Motifs [G02.111.570.820.709.275.500.360.240]
        
        Helix-Turn-Helix Motifs [G02.111.570.820.709.275.500.360.360]
        
        Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]
        
        Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]
        
        Kazal Motifs [G02.111.570.820.709.275.500.490]
        
        Kelch Repeat [G02.111.570.820.709.275.500.500]
        
        Leucine Zippers [G02.111.570.820.709.275.500.520]
        
        Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]
        
        RNA-Binding Motifs [G02.111.570.820.709.275.500.869]
        
        Sterile Alpha Motif [G02.111.570.820.709.275.500.898]
        
        AAA Domain [G02.111.570.820.709.275.500.913]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]
        
        WD40 Repeats [G02.111.570.820.709.275.500.927]
        
        Zinc Fingers [G02.111.570.820.709.275.500.985]

Helix-Loop-Helix Motifs Preferred

Concept UI: M0027486
Scope Note: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical loop segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
Terms: Helix-Loop-Helix Motifs Preferred Term
Term UI T054546
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1994); HLH Motifs
Term UI T362144
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Motifs, Helix-Loop-Helix
Term UI T362145
Date11/03/1999
LexicalTag NON
ThesaurusID NLM (2000); Helix-Loop-Helix Motif
Term UI T000897792
Date03/28/2016
LexicalTag NON
ThesaurusID NLM (2017); Helix-Loop-Helix Domain
Term UI T000897793
Date03/28/2016
LexicalTag NON
ThesaurusID NLM (2017); Helix-Loop-Helix Domains
Term UI T000897794
Date03/28/2016
LexicalTag NON
ThesaurusID NLM (2017)

Helix-Loop-Helix Motifs MeSH Descriptor Data 2025