MeSH Browser

MeSH Heading: Helix-Turn-Helix Motifs
Tree Number(s): G02.111.570.820.709.275.500.360.360
Unique ID: D019077
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019077
Annotation: do not confuse with HELIX-LOOP-HELIX MOTIFS
Scope Note: The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the turn. The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
Entry Term(s): HTH Motifs; Motifs, Helix-Turn-Helix
Previous Indexing: Amino Acid Sequence (1985-1994); Helix-Loop-Helix Motifs (1994-1995)
Public MeSH Note: 96; was see HELIX-LOOP-HELIX MOTIFS 1994-95
Online Note: use HELIX-LOOP-HELIX MOTIFS to search HELIX-TURN-HELIX MOTIFS 1994-95
History Note: 96; was see HELIX-LOOP-HELIX MOTIFS 1994-95
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2016/05/31

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0028477
Scope Note: The first DNA-binding protein motif to be recognized. Helix-turn-helix motifs were originally identified in bacterial proteins but have since been found in hundreds of DNA-BINDING PROTEINS from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the turn. The two helices are held at a fixed angle, primarily through interactions between the two helices. (From Alberts et al., Molecular Biology of the Cell, 3d ed, p408-9)
Terms: Helix-Turn-Helix Motifs Preferred Term
Term UI T056976
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1996); HTH Motifs
Term UI T362149
Date11/05/1999
LexicalTag NON
ThesaurusID NLM (2000); Motifs, Helix-Turn-Helix
Term UI T362150
Date11/05/1999
LexicalTag NON
ThesaurusID NLM (2000)

Helix-Turn-Helix Motifs MeSH Descriptor Data 2024