MeSH Browser

MeSH Heading: DEAD Box Protein 58
Tree Number(s): D08.811.913.696.445.735.720.249.750
Unique ID: D000071457
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071457
Scope Note: A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
Entry Term(s): DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58; Probable ATP-Dependent RNA Helicase DDX58; RIG-I-like Receptor 1
Registry Number: EC 3.6.4.13
Previous Indexing: DEAD-box RNA Helicases (2006-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000614788
Registry Number: EC 3.6.4.13
Scope Note: A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).
Terms: DEAD Box Protein 58 Preferred Term
Term UI T000895558
Date02/18/2016
LexicalTag ACX
ThesaurusID NLM (2017); DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
Term UI T000895561
Date02/18/2016
LexicalTag ABX
ThesaurusID NLM (2017); Probable ATP-Dependent RNA Helicase DDX58
Term UI T000895562
Date02/18/2016
LexicalTag ABX
ThesaurusID NLM (2017); RIG-I-like Receptor 1
Term UI T000895560
Date02/18/2016
LexicalTag ABX
ThesaurusID NLM (2017)

DEAD Box Protein 58 MeSH Descriptor Data 2024