Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Interferon-Induced Helicase, IFIH1 MeSH Descriptor Data 2025


MeSH Heading
Interferon-Induced Helicase, IFIH1
Tree Number(s)
D08.811.913.696.445.735.720.249.875
D12.776.066.125
Unique ID
D000072640
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072640
Scope Note
A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.
Entry Term(s)
CADM-140 Autoantigen
Helicard
IFIH1 Protein
Interferon Induced with Helicase C Domain 1
Interferon-Induced Helicase C Domain-Containing Protein 1
Melanoma Differentiation-Associated Protein 5
Registry Numbers
EC 3.6.4.13
Previous Indexing
DEAD-box RNA Helicases (2006-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2021/05/10
Interferon-Induced Helicase, IFIH1 Preferred
page delivered in 0.171s