MeSH Browser

MeSH Heading: Interferon-alpha
Tree Number(s): D12.644.276.374.440.890.250; D12.776.467.374.440.890.250; D23.529.374.440.890.250
Unique ID: D016898
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016898
Scope Note: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Entry Term(s): IFN-alpha D; IFN-alpha5; Interferon Alfa; Interferon alpha-1; Interferon alpha-17; Interferon alpha-4; Interferon alpha-5; Interferon alpha-7; Interferon alpha-88; Interferon alpha-J; Interferon alpha-T; Interferon alpha4; Interferon alpha5; Interferon, Leukocyte; Interferon, Lymphoblast; Interferon, Lymphoblastoid; Interferon, alpha; LeIF I; LeIF J; Leif D; alpha-Interferon
Pharm Action: Antiviral Agents
Immunologic Factors
Previous Indexing: Interferon Type I (1983-1991)
Public MeSH Note: 1992; see INTERFERON TYPE I 1983-1991, INTERFERON ALPHA-1 was indexed under INTERFERON-ALPHA 2001-2011, INTERFERON-ALPHA 2 was indexed under INTERFERON-ALPHA 1997-2011, INTERFERON ALPHA4 was indexed under INTERFERON-ALPHA 1993-2001, INTERFERON ALPHA5 was indexed under INTERFERON-ALPHA 1996-2001
History Note: 1992; for INTERFERON, LYMPHOBLAST and INTERFERON, LEUKOCYTE use INTERFERON TYPE I 1989-1991
Date Established: 1992/01/01
Date of Entry: 1991/05/30
Revision Date: 2018/01/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Cytokines [D12.644.276.374]
      - Interferons [D12.644.276.374.440]
        
        Interferon Type I [D12.644.276.374.440.890]
        
        Interferon-alpha [D12.644.276.374.440.890.250]
        
        Interferon alpha-2 [D12.644.276.374.440.890.250.500]
        
        Interferon-beta [D12.644.276.374.440.890.275]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Cytokines [D12.776.467.374]
      - Interferons [D12.776.467.374.440]
        
        Interferon Type I [D12.776.467.374.440.890]
        
        Interferon-alpha [D12.776.467.374.440.890.250]
        
        Interferon alpha-2 [D12.776.467.374.440.890.250.500]
        
        Interferon-beta [D12.776.467.374.440.890.275]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Cytokines [D23.529.374]
    - Interferons [D23.529.374.440]
      - Interferon Type I [D23.529.374.440.890]
        
        Interferon-alpha [D23.529.374.440.890.250]
        
        Interferon alpha-2 [D23.529.374.440.890.250.500]
        
        Interferon-beta [D23.529.374.440.890.275]

Interferon-alpha Preferred

Concept UI: M0025711
Scope Note: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Terms: Interferon-alpha Preferred Term
Term UI T050583
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1992); Interferon, alpha
Term UI T050581
Date03/18/1991
LexicalTag NON
ThesaurusID NLM (1992); alpha-Interferon
Term UI T050582
Date03/18/1991
LexicalTag NON
ThesaurusID NLM (1992); Interferon, Lymphoblast
Term UI T050585
Date03/18/1991
LexicalTag NON
ThesaurusID NLM (1992); Interferon Alfa
Term UI T050587
Date03/18/1991
LexicalTag NON
ThesaurusID NLM (1992); Interferon, Lymphoblastoid
Term UI T050590
Date03/18/1991
LexicalTag NON
ThesaurusID NLM (1992); Interferon, Leukocyte
Term UI T050584
Date03/18/1991
LexicalTag NON
ThesaurusID NLM (1992)

Interferon alpha-4 Narrower

Interferon alpha-5 Narrower

Interferon alpha-1 Narrower

Interferon alpha-17 Narrower

Concept UI: M0552551
Terms: Interferon alpha-17 Preferred Term
Term UI T782160
Date12/14/2010
LexicalTag NON
ThesaurusID NLM (2012); LeIF I
Term UI T782163
Date12/14/2010
LexicalTag ABB
ThesaurusID NLM (2012); Interferon alpha-88
Term UI T782161
Date12/14/2010
LexicalTag NON
ThesaurusID NLM (2012); Interferon alpha-T
Term UI T782162
Date12/14/2010
LexicalTag NON
ThesaurusID NLM (2012)

Interferon alpha-7 Narrower

Interferon-alpha MeSH Descriptor Data 2024