Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Interferon-alpha MeSH Descriptor Data 2025


MeSH Heading
Interferon-alpha
Tree Number(s)
D12.644.276.374.440.890.250
D12.776.467.374.440.890.250
D23.529.374.440.890.250
Unique ID
D016898
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016898
Scope Note
One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.
Entry Term(s)
IFN-alpha D
IFN-alpha5
Interferon Alfa
Interferon alpha-1
Interferon alpha-17
Interferon alpha-4
Interferon alpha-5
Interferon alpha-7
Interferon alpha-88
Interferon alpha-J
Interferon alpha-T
Interferon alpha4
Interferon alpha5
Interferon, Leukocyte
Interferon, Lymphoblast
Interferon, Lymphoblastoid
Interferon, alpha
LeIF I
LeIF J
Leif D
alpha-Interferon
Pharm Action
Antiviral Agents
Immunologic Factors
Registry Numbers
0
Previous Indexing
Interferon Type I (1983-1991)
Public MeSH Note
1992; see INTERFERON TYPE I 1983-1991, INTERFERON ALPHA-1 was indexed under INTERFERON-ALPHA 2001-2011, INTERFERON-ALPHA 2 was indexed under INTERFERON-ALPHA 1997-2011, INTERFERON ALPHA4 was indexed under INTERFERON-ALPHA 1993-2001, INTERFERON ALPHA5 was indexed under INTERFERON-ALPHA 1996-2001
History Note
1992; for INTERFERON, LYMPHOBLAST and INTERFERON, LEUKOCYTE use INTERFERON TYPE I 1989-1991
Date Established
1992/01/01
Date of Entry
1991/05/30
Revision Date
2018/01/11
Interferon-alpha Preferred
Interferon alpha-4 Narrower
Interferon alpha-5 Narrower
Interferon alpha-1 Narrower
Interferon alpha-17 Narrower
Interferon alpha-7 Narrower
page delivered in 0.124s