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SAM Domain and HD Domain-Containing Protein 1 MeSH Descriptor Data 2022


MeSH Heading
SAM Domain and HD Domain-Containing Protein 1
Tree Number(s)
D08.811.277.040.725
D08.811.277.352.700.843
D12.776.066.375
Unique ID
D000076106
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076106
Scope Note
A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2).
Entry Term(s)
SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
SAMHD1 Protein
SAMHD1 dNTPase
Registry Number
EC 3.1.5.-
Related Numbers
EC 3.6.-
Previous Indexing
Monomeric GTP-Binding Proteins (2004-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/05/10
SAM Domain and HD Domain-Containing Protein 1 Preferred
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