MeSH Browser

MeSH Heading: APOBEC-3G Deaminase
Tree Number(s): D08.811.277.151.486.250.500.750; D12.776.066.032
Unique ID: D000071480
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071480
Scope Note: An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.
Entry Term(s): APOBEC-3G Protein; APOBEC-3G dC-dU Editing Enzyme; APOBEC-Related Cytidine Deaminase; APOBEC-Related Protein; APOBEC3G Deaminase; APOBEC3G Protein; CEM15 Protein
Registry Number: EC 3.5.4.5
Previous Indexing: Cytidine Deaminase (2007-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2021/05/10

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Aminohydrolases [D08.811.277.151]
      - Nucleoside Deaminases [D08.811.277.151.486]
        
        Cytidine Deaminase [D08.811.277.151.486.250]
        
        APOBEC Deaminases [D08.811.277.151.486.250.500]
        
        APOBEC-1 Deaminase [D08.811.277.151.486.250.500.500]
        
        APOBEC-3G Deaminase [D08.811.277.151.486.250.500.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Antiviral Restriction Factors [D12.776.066]

APOBEC-3G Deaminase Preferred

Concept UI: M000614859
Registry Number: EC 3.5.4.5
Scope Note: An APOBEC deaminase that functions as an inhibitor of RETROVIRIDAE replication and inhibits the mobility of RETROTRANSPOSONS via deaminase-dependent and independent mechanisms. It is selective for SINGLE-STRANDED DNA and does not deaminate double-stranded DNA or single or DOUBLE-STRANDED RNA. It exhibits potent antiviral activity against VIF PROTEIN deficient HIV-1 through the creation of hypermutations in the VIRAL DNA. It also has anti-viral activity against SIMIAN IMMUNODEFICIENCY VIRUSES and HEPATITIS B VIRUS.
Terms: APOBEC-3G Deaminase Preferred Term
Term UI T000895634
Date02/19/2016
LexicalTag ACX
ThesaurusID NLM (2017); APOBEC-Related Cytidine Deaminase
Term UI T000895636
Date02/19/2016
LexicalTag ACX
ThesaurusID NLM (2017); APOBEC3G Protein
Term UI T000895641
Date02/19/2016
LexicalTag ACX
ThesaurusID NLM (2017); CEM15 Protein
Term UI T000895638
Date02/19/2016
LexicalTag ABX
ThesaurusID NLM (2017); APOBEC3G Deaminase
Term UI T000895639
Date02/19/2016
LexicalTag ACX
ThesaurusID NLM (2017); APOBEC-3G Protein
Term UI T000895640
Date02/19/2016
LexicalTag ACX
ThesaurusID NLM (2017); APOBEC-Related Protein
Term UI T000895635
Date02/19/2016
LexicalTag ACX
ThesaurusID NLM (2017); APOBEC-3G dC-dU Editing Enzyme
Term UI T000895637
Date02/19/2016
LexicalTag ACX
ThesaurusID NLM (2017)

APOBEC-3G Deaminase MeSH Descriptor Data 2024