MeSH Browser

MeSH Heading: Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases
Tree Number(s): D08.811.277.352.650.624.750
Unique ID: D000072183
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072183
Scope Note: Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
Entry Term(s): SHIP Phosphatases; Src Homology 2 Domain-Containing Inositol Phosphatases
Registry Number: EC 3.1.3.86
Previous Indexing: Phosphoric Monoester Hydrolases (1996-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000616490
Registry Number: EC 3.1.3.86
Scope Note: Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.
Terms: Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases Preferred Term
Term UI T000898420
Date04/06/2016
LexicalTag NON
ThesaurusID NLM (2017); Src Homology 2 Domain-Containing Inositol Phosphatases
Term UI T000898422
Date04/06/2016
LexicalTag NON
ThesaurusID NLM (2017); SHIP Phosphatases
Term UI T000898421
Date04/06/2016
LexicalTag ACX
ThesaurusID NLM (2017)

Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases MeSH Descriptor Data 2024