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A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS.
Entry Term(s)
ADAM 12 Protein
ADAM-12 Protein
ADAM12-L Protein
ADAM12-S Protein
Disintegrin and Metalloproteinase Domain-Containing Protein 12
Meltrin-alpha Protein
Registry Numbers
EC 3.4.24.-
0
Related Numbers
EC 3.4.24.82
Public MeSH Note
2017; ADAM12 PROTEIN was indexed under MEMBRANE PROTEINS and ADAM PROTEINS 2006-2016; and under METALLOENDOPEPTIDASES 1997-2005
A disintegrin and metalloproteinase domain-containing protein that is expressed as two alternatively-spliced forms: a long transmembrane form (ADAM12-L) and a short soluble form (ADAM12-S). It modulates the cleavage of INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS and may also regulate CELL FUSION during MYOGENESIS.