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ADAM17 Protein MeSH Descriptor Data 2022


MeSH Heading
ADAM17 Protein
Tree Number(s)
D08.811.277.656.675.374.102.375
D09.400.430.500.375
D12.776.395.033.375
Unique ID
D000072198
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000072198
Scope Note
A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.
Entry Term(s)
ADAM-17
ADAM-17 Protein
CD156b Antigen
Disintegrin and Metalloproteinase Domain-Containing Protein 17
TACA (Enzyme)
TACE (Enzyme)
TNF-alpha Convertase
TNF-alpha Converting Enzyme
Tumor Necrosis Factor Alpha Convertase
Tumor Necrosis Factor-alpha Convertase
Tumor Necrosis Factor-alpha Converting Enzyme
Registry Number
EC 3.4.24.86
Public MeSH Note
2017; ADAM17 PROTEIN was indexed under ADAM PROTEINS 2005-2016, and under METALLOENDOPEPTIDASES 1996-2005
History Note
2017 (1996)
Date Established
2017/01/01
Date of Entry
2016/07/06
Revision Date
2017/05/24
ADAM17 Protein Preferred
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