MeSH Browser

MeSH Heading: Connexin 26
Tree Number(s): D12.776.543.585.250.100
Unique ID: D000072259
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072259
Scope Note: A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
Entry Term(s): Connexin Cx26; Connexin beta-2; Gap Junction beta-2 protein; beta2 Connexin
Registry Number: 127120-53-0
Public MeSH Note: 2017; CONNEXIN 26 was indexed under CONNEXINS 1993-2016
History Note: 2017 (1993)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0220781
Registry Number: 127120-53-0
Scope Note: A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
Terms: Connexin 26 Preferred Term
Term UI T000898812
Date04/12/2016
LexicalTag NON
ThesaurusID NLM (2017); beta2 Connexin
Term UI T000899724
Date04/25/2016
LexicalTag NON
ThesaurusID NLM (2017); Connexin beta-2
Term UI T000902764
Date06/13/2016
LexicalTag NON
ThesaurusID NLM (2017); Connexin Cx26
Term UI T000899723
Date04/25/2016
LexicalTag NON
ThesaurusID NLM (2017)

Connexin 26 MeSH Descriptor Data 2024