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Oxaliplatin MeSH Descriptor Data 2024


MeSH Heading
Oxaliplatin
Tree Number(s)
D02.257.750
Unique ID
D000077150
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077150
Scope Note
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
Entry Term(s)
1,2-Diaminocyclohexane Platinum Oxalate
1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
ACT 078
ACT-078
Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II)
Eloxatin
Eloxatine
L-OHP Cpd
Oxalato-(1,2-cyclohexanediamine)platinum II
Oxaliplatin, (SP-4-2-(1R-trans))-isomer
Oxaliplatin, (SP-4-2-(1S-trans))-isomer
Oxaliplatin, (SP-4-3-(cis))-isomer
Oxaliplatine
Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
Platinum(II)-1,2-cyclohexanediamine Oxalate
Pharm Action
Antineoplastic Agents
Registry Number
04ZR38536J
Related Numbers
61758-77-8
61913-68-6
Public MeSH Note
2019; OXALIPLATIN was indexed under ORGANOPLATINUM COMPOUNDS 1981-2018
History Note
2019 (1981)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2019/07/05
Oxaliplatin Preferred
Eloxatine Narrower
Eloxatin Narrower
Oxaliplatin, (SP-4-3-(cis))-isomer Narrower
ACT 078 Narrower
Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II) Narrower
Oxaliplatin, (SP-4-2-(1S-trans))-isomer Narrower
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