MeSH Browser

MeSH Heading: Oxaliplatin
Tree Number(s): D02.257.750
Unique ID: D000077150
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077150
Scope Note: An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
Entry Term(s): 1,2-Diaminocyclohexane Platinum Oxalate; 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II); ACT 078; ACT-078; Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II); Eloxatin; Eloxatine; L-OHP Cpd; Oxalato-(1,2-cyclohexanediamine)platinum II; Oxaliplatin, (SP-4-2-(1R-trans))-isomer; Oxaliplatin, (SP-4-2-(1S-trans))-isomer; Oxaliplatin, (SP-4-3-(cis))-isomer; Oxaliplatine; Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1); Platinum(II)-1,2-cyclohexanediamine Oxalate
Pharm Action: Antineoplastic Agents
Registry Number: 04ZR38536J
Related Numbers: 61758-77-8; 61913-68-6
Public MeSH Note: 2019; OXALIPLATIN was indexed under ORGANOPLATINUM COMPOUNDS 1981-2018
History Note: 2019 (1981)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2019/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Organic Chemicals [D02]
- Coordination Complexes [D02.257]

Oxaliplatin Preferred

Concept UI: M0095550
Registry Number: 04ZR38536J
Related Numbers: 61758-77-8; 61913-68-6
Scope Note: An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.
Terms: Oxaliplatin Preferred Term
Term UI T000936956
Date11/30/2017
LexicalTag NON
ThesaurusID; Oxalato-(1,2-cyclohexanediamine)platinum II
Term UI T000937036
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (1981); Oxaliplatin, (SP-4-2-(1R-trans))-isomer
Term UI T000937037
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (1981); L-OHP Cpd
Term UI T000937035
Date12/01/2017
LexicalTag ABB
ThesaurusID NLM (2011); Platinum(II)-1,2-cyclohexanediamine Oxalate
Term UI T000937039
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (1981); 1,2-Diaminocyclohexane Platinum Oxalate
Term UI T000937033
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (1981); 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II)
Term UI T000937034
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (1981); Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
Term UI T000962381
Date06/26/2019
LexicalTag NON
ThesaurusID NLM (2020); Oxaliplatine
Term UI T000937038
Date12/01/2017
LexicalTag NON
ThesaurusID NLM (2001)

Eloxatine Narrower

Eloxatin Narrower

Oxaliplatin, (SP-4-3-(cis))-isomer Narrower

ACT 078 Narrower

Cis-oxalato-(trans-l)-1,2-diaminocyclohexane-platinum(II) Narrower

Oxaliplatin, (SP-4-2-(1S-trans))-isomer Narrower

Oxaliplatin MeSH Descriptor Data 2024